The significant role of green chemistry in circular economy projects will be discussed, with a particular emphasis on territorial approaches for waste and biomass valorization and the utilization of unconventional activation methods such as sonochemistry, microwave chemistry, and pressurized fluids. The presentation will showcase several examples of projects that utilize these innovative techniques for the production of valuable molecules within the context of the bioeconomy and circular economy. Emphasis will be placed on the importance of multidisciplinary collaboration and territorial strategies in achieving sustainable solutions. Several case studies will be presented, including a local-scale project that focuses on the valorization of viticultural waste through a cascade of valorization processes and various applications. Additionally, the establishment of a start-up dedicated to the valorization of invasive plants for favouring the biodiversity preservation, utilizing an innovative laboratory-developed process, will be highlighted. Furthermore, an initiative that utilizes supercritical CO2-based processes to valorize coffee grounds collected from local restaurants for the production of molecules of interest in cosmetic and nutraceutical applications will be discussed. The presentation will also delve into recent research on the valorization of apple pomace for antibacterial applications. More globally, the integration of green chemistry strategies through multidisciplinary and multi-actor approaches is essential for effectively transforming territorial challenges into innovative solutions.